The Vernon lab is an inter-disciplinary research group, which aims to address the lack of continuity between the levels of analysis used in animal models and clinical research into brain disorders. To fill this gap, we have developed a cutting edge biomedical imaging approach, comprising in vivo Magnetic Resonance Imaging (MRI; clinically comparable technology) and ex vivo 3D imaging of intact brain tissue (CLARITY), coupled with post-mortem cellular and molecular analyses. We can therefore recapitulate precise correlates of specific neural systems from rodents to humans. We apply this powerful systems level, translational approach to our primary research questions: (1) Understanding the effects of psychotropic drugs, such as antipsychotics and antidepressants, on the nervous, immune and endocrine systems. By advancing our understanding of the long-term impact of psychotropic drug treatment, this will inform the clinical use of these drugs and help design novel therapies with improved response rate and risk: benefit profiles. (2) To understand how alterations in brain structure and function observed in patients with psychiatric and neurological disorders align with appropriate rodent models. This is crucial to validate subsequent observations in animal models at the cellular and network levels, to speed the development and testing of novel drugs and biomarkers for patient stratification and measuring drug efficacy. We collaborate actively with labs at KCL, other UK and international academic institutions and industrial partners.