All Group Leaders 

Mark  Richardson

Mark Richardson

Paul Getty III Professor in Epilepsy

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Overview

The Richardson Lab, headed by Professor Mark Richardson, comprises a team of epilepsy researchers from several different disciplines, including neurology, psychology, engineering and physics. We study the human brain as an entire functioning system, rather than studying small components of the brain. In order to do this, we use brain scanning techniques (especially MRI) and electroencephalography (EEG, a method to record electrical activity from the brain), as well as transcranial magnetic brain stimulation (TMS). We are especially interested to create simplified models of the brain using computers, which can provide important insights into the workings of the highly complex brain. Our current programme is focussed on understanding how seizures emerge as the result of the complex interplay between the neuronal dynamics of localised brain regions, and the interconnectivity between these regions. We are particularly interested to discover whether these features are genetically determined, and how these features develop through childhood and into adult life.

Selected publications

Antony AR, Abramovici S, Krafty RT, Pan J, Richardson M, Bagic A, Haneef Z (2018) Simultaneous scalp EEG improves seizure lateralization during unilateral intracranial EEG evaluation in temporal lobe epilepsy. Seizure 64: 8-15
Perani S, Tierney TM, Centeno M, Shamshiri EA, Yaakub SN, O'Muircheartaigh J, Carmichael DW, Richardson MP (2017) Thalamic volume reduction in drug-naive patients with new-onset genetic generalized epilepsy. Epilepsia

Chowdhury FA, Pawley AD, Ceronie B, Nashef L, Elwes RD, Richardson MP (2015) Motor evoked potential polyphasia: a novel endophenotype of idiopathic generalized epilepsy. Neurology 84: 1301-7
Keller SS, Richardson MP, O'Muircheartaigh J, Schoene-Bake JC, Elger C, Weber B (2015) Morphometric MRI alterations and postoperative seizure control in refractory temporal lobe epilepsy. Hum Brain Mapp 36: 1637-47
Towgood K, Barker GJ, Caceres A, Crum WR, Elwes RD, Costafreda SG, Mehta MA, Morris RG, von Oertzen TJ, Richardson MP (2015) Bringing memory fMRI to the clinic: comparison of seven memory fMRI protocols in temporal lobe epilepsy. Hum Brain Mapp 36: 1595-608
Keller SS, Richardson MP, Schoene-Bake JC, O'Muircheartaigh J, Elkommos S, Kreilkamp B, Goh YY, Marson AG, Elger C, Weber B (2015) Thalamotemporal alteration and postoperative seizures in temporal lobe epilepsy. Ann Neurol 77: 760-74
Chowdhury FA, Woldman W, FitzGerald TH, Elwes RD, Nashef L, Terry JR, Richardson MP (2014) Revealing a brain network endophenotype in families with idiopathic generalised epilepsy. PLoS One 9: e110136
Schmidt H, Petkov G, Richardson MP, Terry JR (2014) Dynamics on networks: the role of local dynamics and global networks on the emergence of hypersynchronous neural activity. PLoS Comput Biol 10: e1003947
Benjamin O, Fitzgerald TH, Ashwin P, Tsaneva-Atanasova K, Chowdhury F, Richardson MP, Terry JR (2012) A phenomenological model of seizure initiation suggests network structure may explain seizure frequency in idiopathic generalised epilepsy. J Math Neurosci 2: 1
Terry JR, Benjamin O, Richardson MP (2012) Seizure generation: the role of nodes and networks. Epilepsia 53: e166-9
O'Muircheartaigh J, Vollmar C, Barker GJ, Kumari V, Symms MR, Thompson P, Duncan JS, Koepp MJ, Richardson MP (2012) Abnormal thalamocortical structural and functional connectivity in juvenile myoclonic epilepsy. Brain 135: 3635-44
Richardson MP (2012) Large scale brain models of epilepsy: dynamics meets connectomics. J Neurol Neurosurg Psychiatry 83: 1238-48
O'Muircheartaigh J, Vollmar C, Traynor C, Barker GJ, Kumari V, Symms MR, Thompson P, Duncan JS, Koepp MJ, Richardson MP (2011) Clustering probabilistic tractograms using independent component analysis applied to the thalamus. Neuroimage 54: 2020-32
O'Muircheartaigh J, Vollmar C, Barker GJ, Kumari V, Symms MR, Thompson P, Duncan JS, Koepp MJ, Richardson MP (2011) Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy. Neurology 76: 34-40
Richardson MP (2011) New observations may inform seizure models: very fast and very slow oscillations. Prog Biophys Mol Biol 105: 5-13
Traynor CR, Barker GJ, Crum WR, Williams SC, Richardson MP (2011) Segmentation of the thalamus in MRI based on T1 and T2. Neuroimage 56: 939-50
Richardson M (2010) Current themes in neuroimaging of epilepsy: brain networks, dynamic phenomena, and clinical relevance. Clin Neurophysiol 121: 1153-75
Traynor C, Heckemann RA, Hammers A, O'Muircheartaigh J, Crum WR, Barker GJ, Richardson MP (2010) Reproducibility of thalamic segmentation based on probabilistic tractography. Neuroimage 52: 69-85
Richardson MP, Strange BA, Duncan JS, Dolan RJ (2006) Memory fMRI in left hippocampal sclerosis: optimizing the approach to predicting postsurgical memory. Neurology 66: 699-705
Richardson MP, Grosse P, Allen PJ, Turner R, Brown P (2006) BOLD correlates of EMG spectral density in cortical myoclonus: description of method and case report. Neuroimage 32: 558-65
Wright MA, Orth M, Patsalos PN, Smith SJ, Richardson MP (2006) Cortical excitability predicts seizures in acutely drug-reduced temporal lobe epilepsy patients. Neurology 67: 1646-51
Powell HW, Koepp MJ, Symms MR, Boulby PA, Salek-Haddadi A, Thompson PJ, Duncan JS, Richardson MP (2005) Material-specific lateralization of memory encoding in the medial temporal lobe: blocked versus event-related design. Neuroimage 27: 231-9
Richardson MP, Strange BA, Dolan RJ (2004) Encoding of emotional memories depends on amygdala and hippocampus and their interactions. Nat Neurosci 7: 278-85
Vuilleumier P, Richardson MP, Armony JL, Driver J, Dolan RJ (2004) Distant influences of amygdala lesion on visual cortical activation during emotional face processing. Nat Neurosci 7: 1271-8