All Group Leaders 

David  Edwards

David Edwards

Chair in Paediatrics and Neonatal Medicine

  |  Website

Overview

David Edwards is Professor of Paediatrics and Neonatal Medicine, and Director of the Centre for the Developing Brain at King’s College London, and Consultant Neonatologist at Guy’s and St Thomas’ Hospital NHS Trust. He was educated at Oxford University, Harvard University, London University and trained with Osmund Reynolds at University College London. In 1992 he was appointed the foundation Weston Professor of Neonatal Medicine at the Royal Postgraduate Medical School, which later joined with Imperial College London. He moved with his group to King’s College London in 2012 to establish the Centre for the Developing Brain with £7.2m of funding from the Medical Research Council. His research group aims to reduce the number of infants suffering brain damage in the perinatal period, and took a leading role in the laboratory and clinical research that led to the discovery and implementation of neural rescue therapy for birth asphyxia. They also established the first dedicated neonatal MR scanner and the development of MR imaging to study perinatal problems. He currently leads the €15million Developing Human Connectome Project funded by the European Research Council.

His research goal is to reduce the number of children who suffer lifelong impairment because of brain injury about the time of birth. He and his colleagues are credited with the discovery and implementation of the first effective therapy to reduce brain damage after birth asphyxia; hypothermic neural rescue therapy doubles the chance of normal survival in affected infants. His group now is increasingly focused on machine learning and imaging genetics as a way to understand the problems of preterm infants.

Selected publications

Krishnan ML, Wang Z, Aljabar P, Ball G, Mirza G, Saxena A, Counsell SJ, Hajnal JV, Montana G, Edwards AD (2017) Machine learning shows association between genetic variability in PPARG and cerebral connectivity in preterm infants. Proc Natl Acad Sci U S A 114: 13744-13749

Ball G, Aljabar P, Nongena P, Kennea N, Gonzalez-Cinca N, Falconer S, Chew ATM, Harper N, Wurie J, Rutherford MA, Counsell SJ, Edwards AD (2017) Multimodal image analysis of clinical influences on preterm brain development. Ann Neurol 82: 233-246
Edwards AD, Redshaw ME, Kennea N, Rivero-Arias O, Gonzales-Cinca N, Nongena P, Ederies M, Falconer S, Chew A, Omar O, Hardy P, Harvey ME, Eddama O, Hayward N, Wurie J, Azzopardi D, Rutherford MA, Counsell S (2017) Effect of MRI on preterm infants and their families: a randomised trial with nested diagnostic and economic evaluation. Arch Dis Child Fetal Neonatal Ed
Tusor N, Benders MJ, Counsell SJ, Nongena P, Ederies MA, Falconer S, Chew A, Gonzalez-Cinca N, Hajnal JV, Gangadharan S, Chatzi V, Kersbergen KJ, Kennea N, Azzopardi DV, Edwards AD (2017) Punctate White Matter Lesions Associated With Altered Brain Development And Adverse Motor Outcome In Preterm Infants. Sci Rep 7: 13250
Toulmin H, Beckmann CF, O'Muircheartaigh J, Ball G, Nongena P, Makropoulos A, Ederies A, Counsell SJ, Kennea N, Arichi T, Tusor N, Rutherford MA, Azzopardi D, Gonzalez-Cinca N, Hajnal JV, Edwards AD (2015) Specialization and integration of functional thalamocortical connectivity in the human infant. Proc Natl Acad Sci U S A 112: 6485-90
Counsell SJ, Ball G, Edwards AD (2014) New imaging approaches to evaluate newborn brain injury and their role in predicting developmental disorders. Curr Opin Neurol 27: 168-75
Tusor N, Arichi T, Counsell SJ, Edwards AD (2014) Brain development in preterm infants assessed using advanced MRI techniques. Clin Perinatol 41: 25-45
Ball G, Aljabar P, Zebari S, Tusor N, Arichi T, Merchant N, Robinson EC, Ogundipe E, Rueckert D, Edwards AD, Counsell SJ (2014) Rich-club organization of the newborn human brain. Proc Natl Acad Sci U S A 111: 7456-61
Ball G, Srinivasan L, Aljabar P, Counsell SJ, Durighel G, Hajnal JV, Rutherford MA, Edwards AD (2013) Development of cortical microstructure in the preterm human brain. Proc Natl Acad Sci U S A 110: 9541-6
Doria V, Beckmann CF, Arichi T, Merchant N, Groppo M, Turkheimer FE, Counsell SJ, Murgasova M, Aljabar P, Nunes RG, Larkman DJ, Rees G, Edwards AD (2010) Emergence of resting state networks in the preterm human brain. Proc Natl Acad Sci U S A 107: 20015-20
Gluckman PD, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, Polin RA, Robertson CM, Thoresen M, Whitelaw A, Gunn AJ (2005) Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 365: 663-70