All Group Leaders 

Synapse formation and autism

Laura Andreae

Laura Andreae

Reader

  |  Website

Overview

My lab is interested in how synaptic connections and neuronal circuits are formed during development, and how these processes may be disrupted in neurodevelopmental disorders such as autism, epilepsy and schizophrenia. We use a variety of approaches, including electrophysiology and advanced imaging techniques, to investigate how neuronal activity regulates early synapse formation and to further our understanding of the mechanisms that lead to alterations in neural circuit development and function in genetic models of neurodevelopmental disorders. 

Laura Andreae is the Training Director for the MRC-Sackler PhD Programme 

Selected publications

Ellingford RA, Panasiuk MJ, de Meritens ER, Shaunak R, Naybour L, Browne L, Basson MA, Andreae LC (2021) Cell-type-specific synaptic imbalance and disrupted homeostatic plasticity in cortical circuits of ASD-associated Chd8 haploinsufficient mice. Mol Psychiatry 26: 3614-3624
Pervolaraki E, Tyson AL, Pibiri F, Poulter SL, Reichelt AC, Rodgers RJ, Clapcote SJ, Lever C, Andreae LC, Dachtler J (2019) The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice Mol Autism 10: 8
Taylor RD, Heine M, Emptage NJ, Andreae LC (2018) Neuronal Receptors Display Cytoskeleton-Independent Directed Motion on the Plasma Membrane. iScience 10: 234-244
Andreae LC, Burrone J (2015) Spontaneous Neurotransmitter Release Shapes Dendritic Arbors via Long-Range Activation of NMDA Receptors. Cell Rep 15: S2211-1247