Synapse formation and autism
My lab is interested in how synaptic connections and neuronal circuits are formed during development, and how these processes may be disrupted in neurodevelopmental disorders such as autism and schizophrenia. We use a variety of techniques including electrophysiology, structural and functional imaging in both rodent models and human inducible pluripotent stem cells, to address these questions. We have strong connections with psychiatrists at the Institute of Psychiatry (KCL), working together with clinicians to try to understand the underlying pathophysiology of these disorders, with the eventual goal of finding new treatments.
Tyson AL, Hilton ST, Andreae LC
(2015) Rapid, simple and inexpensive production of custom 3D printed equipment for large-volume fluorescence microscopy. Int J Pharm
Andreae LC, Burrone J
(2015) Spontaneous Neurotransmitter Release Shapes Dendritic Arbors via Long-Range Activation of NMDA Receptors. Cell Rep