All Group Leaders 

Synapse formation and autism

Laura Andreae

Laura Andreae

Lecturer

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Overview

My lab is interested in how synaptic connections and neuronal circuits are formed during development, and how these processes may be disrupted in neurodevelopmental disorders such as autism and schizophrenia. We use a variety of techniques including electrophysiology, structural and functional imaging in both rodent models and human inducible pluripotent stem cells, to address these questions. We have strong connections with psychiatrists at the Institute of Psychiatry (KCL), working together with clinicians to try to understand the underlying pathophysiology of these disorders, with the eventual goal of finding new treatments.

Selected publications

Tyson AL, Hilton ST, Andreae LC (2015) Rapid, simple and inexpensive production of custom 3D printed equipment for large-volume fluorescence microscopy. Int J Pharm 494: 651-6
Andreae LC, Burrone J (2015) Spontaneous Neurotransmitter Release Shapes Dendritic Arbors via Long-Range Activation of NMDA Receptors. Cell Rep 15: S2211-1247

Aigner S, Heckel T, Zhang JD, Andreae LC, Jagasia R (2014) Human pluripotent stem cell models of autism spectrum disorder: emerging frontiers, opportunities, and challenges towards neuronal networks in a dish. Psychopharmacology (Berl) 231: 1089-104
Andreae LC, Fredj NB, Burrone J (2012) Independent vesicle pools underlie different modes of release during neuronal development. J Neurosci 32: 1867-74
Morice E, Andreae LC, Cooke SF, Vanes L, Fisher EM, Tybulewicz VL, Bliss TV (2008) Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome. Learn Mem 15: 492-500