All Group Leaders 

Molecular mechanisms underlying neural connectivity

Robert Hindges

Robert Hindges

Professor of Developmental Neurobiology

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Overview

Many neuro­developmental disorders are associated with mutations in genes involved in the wiring of the brain, including the formation of cell type-specific synapses, which is crucial for the normal functioning of the brain. The Hindges Lab concentrates on the validation of gene candidates that were associated with different disorders through genetic linkage studies. Using zebrafish, the group assesses the consequences of gene mutations on the molecular and cellular mechanisms underlying neural circuit formation and animal behaviour. Particular focuses are major depressive disorder, schizo­phrenia, bi­polar disorder and autism-related aggression.

Major techniques in the lab include state-of-the-art genome editing, bio­chemical assessments, in vivo structural and functional brain imaging, and a variety of animal behaviour paradigms relevant to the individual disorders. Finally, zebrafish high-throughput approaches allow small-molecule or general pharma­cological screens aimed at identifying compounds to develop novel therapeutic strategies.

Besides his role as a Principle Investigator, Robert Hindges is the Managing Director of the Centre for Developmental Neurobiology and Academic Head of the KCL Genome Editing and Embryology Core Facility (GEEC@KCL), which offers state-of-the-art technologies to the research community.

Selected publications

Cheung A., Schachermayer G., Biehler A., Wallis A., Missaire M. & Hindges R. (2022)

Teneurin paralogues are able to localise synaptic sites driven by the intracellular domain and have the potential to form cis-heterodimers

Frontiers in Neuroscience

Cheung A, Trevers KE, Reyes-Corral M, Antinucci P, Hindges R (2019) Expression and Roles of Teneurins in Zebrafish. Front Neurosci 13: 158

Antinucci P, Hindges R (2016) A crystal-clear zebrafish for in vivo imaging. Sci Rep 6: 29490
Antinucci P, Suleyman O, Monfries C, Hindges R (2016) Neural Mechanisms Generating Orientation Selectivity in the Retina. Curr Biol 26: 1802-15