All Group Leaders 

Declan  Murphy

Declan Murphy

Professor of Psychiatry and Brain Maturation

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The Murphy group ‘translates’ findings from the laboratory to the clinic; mainly through identification of new molecular targets, the development of stratification/­outcome biomarkers, and the testing of potential new treatments on cellular, circuit, or brain function. This work is underpinned by collaborations within the MRC Centre focussing on experiments using iPSC models and rodents that are translated into humans – and back. His laboratory's current focus in autism is the pathological impact of specific genetic and environmental risk factors (including ‘two hit’ models); and the role of serotonin, neuropeptides, glutamate and GABA. Their work in humans includes large scale longitudinal studies of brain development and function (including of the excitatory-inhibitory system) in utero, and from infancy through to adulthood.

Selected publications

Ecker C, Andrews DS, Gudbrandsen CM, Marquand AF, Ginestet CE, Daly EM, Murphy CM, Lai MC, Lombardo MV, Ruigrok AN, Bullmore ET, Suckling J, Williams SC, Baron-Cohen S, Craig MC, Murphy DG, (2017) Association Between the Probability of Autism Spectrum Disorder and Normative Sex-Related Phenotypic Diversity in Brain Structure. JAMA Psychiatry 74: 329-338