Calzolari F, Berninger B (2021) cAAVe phaenomena: Beware of appearances! Cell 184: 5303-5305

In this issue of Cell, Wang et al. come to the unsettling conclusion that adeno-associated viruses, despite being engineered for glia-specific expression, can become widely active in endogenous neurons, misleading researchers in their quest for efficient conversion of glia into neurons for brain repair.

Pubmed: 34653366