Chai A, Mateus AM, Oozeer F, Sousa-Nunes R (2018)
Spatiotemporally controlled genetic perturbation for efficient large-scale studies of cell non-autonomous effects.Elife
Studies in genetic model organisms have revealed much about the development and pathology of complex tissues. Most have focused on cell-intrinsic gene functions and mechanisms. Much less is known about how transformed, or otherwise functionally disrupted, cells interact with healthy ones toward a favorable or pathological outcome. This is largely due to technical limitations. We developed new genetic tools in
