Setsuko Sahara

Setsuko Sahara

Lecturer, Group Leader



Biography:

Setsuko Sahara obtained her PhD from Kobe University followed by a period of training at the Osaka University as a biochemist and cellular biologist. She then joined the lab of Dennis O’Leary’ at the Salk Institute, as a postdoctoral fellow, where she initiated her study of mammalian corticogenesis. In the O’Leary lab, Setsuko found a key regulator of cortical progenitor differentiation. In 2012, she joined the Centre for Developmental Neurobiology, where she is a Lecturer. Her research focuses on understanding the molecular mechanism of cortical progenitor differentiation towards the development of regenerative strategies of the central nervous system. Setsuko’s research also focuses on neurodevelopmental disorders of the cortex such as macrocephaly and autism.

Links:

KCL PURE: https://kclpure.kcl.ac.uk/portal/setsuko.sahara.html

Related News:

Deciphering the tubulin code

24/02/20
Tuba8 has an instructive role in progenitor differentiation

Selected publications:

Ramos SI, Makeyev EV, Salierno M, Kodama T, Kawakami Y, Sahara S (2020) Tuba8 Drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini. Dev Cell 52: 477-491.e8
Kawaguchi D, Sahara S, Zembrzycki A, O'Leary DDM (2016) Generation and analysis of an improved Foxg1-IRES-Cre driver mouse line. Dev Biol 412: 139-147

Zembrzycki A, Stocker AM, Leingärtner A, Sahara S, Chou SJ, Kalatsky V, May SR, Stryker MP, O'Leary DD (2015) Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas. Elife 4
Sahara S, Yanagawa Y, O'Leary DD, Stevens CF (2012) The fraction of cortical GABAergic neurons is constant from near the start of cortical neurogenesis to adulthood. J Neurosci 32: 4755-61