Benedikt  Berninger

Benedikt Berninger

Professor of Developmental Neurobiology, Group Leader



Biography:

Benedikt Berninger was born in Munich in 1968. He graduated in Biology from the Ludwig Maximilians University (Munich, Germany) in 1992. He obtained his Doctoral Degree from the same university for work he had conducted at the Max-Planck Institute of Psychiatry (now Neurobiology) in the laboratory of Hans Thoenen. He subsequently joined the University of California in San Diego as a postdoctoral fellow in the laboratory of Mu-ming Poo during which time he was supported by a Human Frontier Science Program (HFSP) Long-term Fellowship. After a brief stay at the Karolinska Institute in the laboratory of Jonas Fris?n funded by HFSP, he took a group leader position at the Max Planck Institute of Neurobiology in Munich in 2001. Subsequently he became staff scientist at the Helmholtz Center Munich (2003) in the laboratory of Magdalena G?tz. In 2005 he became lecturer at the Institute of Physiology where he habilitated in Physiology in 2011. In 2012 he joined the University Medical Center of the Johannes Gutenberg University as Full Professor. From March 2018 he is Professor of Developmental Neurobiology at the Centre for Developmental Neurobiology at King?s College London and member of the MRC Centre for Neurodevelopmental Disorders.Benedikt is a Wellcome Trust Investigator.

Related News:

Linking adult neural stem cell activation and tumourigenesis

14/04/23
New work from the Berninger lab

Benedikt Berninger awarded ERC Advanced Grant

22/04/21
Unleashing the potential of engineered neurogenesis for brain repair

The sweet smell of adult neurogenesis

05/02/19
Adult olfactory bulb neurogenesis improves odour distinction

All publications:

2023

Péron S, Miyakoshi LM, Brill MS, Manzano-Franco D, Serrano-López J, Fan W, Marichal N, Ghanem A, Conzelmann KK, Karow M, Ortega F, Gascón S, Berninger B (2023) Programming of neural progenitors of the adult subependymal zone towards a glutamatergic neuron lineage by neurogenin 2. Stem Cell Reports
Beltrán Arranz A, Berninger B (2023) Seizing hope: Advancing cell therapy for pharmaco-resistant epilepsy toward the clinic. Cell Stem Cell 30: 1287-1289.

Felske T, Tocco C, Péron S, Harb K, Alfano C, Galante C, Berninger B, Studer M (2023) Lmo4 synergizes with Fezf2 to promote direct in vivo reprogramming of upper layer cortical neurons and cortical glia towards deep-layer neuron identities. PLoS Biol 21(8): e3002237.

Fan W, Jurado-Arjona J, Alanis-Lobato G, Péron S, Berger C, Andrade-Navarro MA, Falk S, Berninger B (2023) The transcriptional co-activator Yap1 promotes adult hippocampal neural stem cell activation. EMBO J : e110384.

2022

Galante C, Marichal N, Scarante FF, Ghayad LM, Shi Y, Schuurmans C, Berninger B, Péron S (2022) Enhanced proliferation of oligodendrocyte progenitor cells following retrovirus mediated Achaete-scute complex-like 1 overexpression in the postnatal cerebral cortex in vivo. Front Neurosci 16: 919462
Cooper A, Berninger B (2022) Gatekeeping astrocyte identity. Elife 11
Leschik J, Gentile A, Cicek C, Péron S, Tevosian M, Beer A, Radyushkin K, Bludau A, Ebner K, Neumann I, Singewald N, Berninger B, Lessmann V, Lutz B (2022) Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis. Prog Neurobiol 217: 102333

2021

Lattke M, Goldstone R, Ellis JK, Boeing S, Jurado-Arjona J, Marichal N, MacRae JI, Berninger B, Guillemot F (2021) Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture. Nat Commun 12: 4335
Sharif N, Calzolari F, Berninger B (2021) Direct In Vitro Reprogramming of Astrocytes into Induced Neurons. Methods Mol Biol 2352: 13-29
Stricker SH, Berninger B, Götz M (2021) Editorial overview: Fluidity of cell fates - from reprogramming to repair. Curr Opin Genet Dev 70: iii-v
Calzolari F, Berninger B (2021) cAAVe phaenomena: Beware of appearances! Cell 184: 5303-5305

2019

Kang E, Song J, Lin Y, Park J, Lee JH, Hussani Q, Gu Y, Ge S, Li W, Hsu KS, Berninger B, Christian KM, Song H, Ming GL (2019) Interplay between a Mental Disorder Risk Gene and Developmental Polarity Switch of GABA Action Leads to Excitation-Inhibition Imbalance. Cell Rep 28: 1419-1428.e3
Bragado Alonso S, Reinert JK, Marichal N, Massalini S, Berninger B, Kuner T, Calegari F (2019) An increase in neural stem cells and olfactory bulb adult neurogenesis improves discrimination of highly similar odorants. EMBO J

2018

Zhao S, Fan W, Guo X, Xue L, Berninger B, Salierno MJ, Del Campo A (2018) Microenvironments to study migration and somal translocation in cortical neurons. Biomaterials 156: 238-247

2017

Azim K, Angonin D, Marcy G, Pieropan F, Rivera A, Donega V, Cantù C, Williams G, Berninger B, Butt AM, Raineteau O (2017) Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity. PLoS Biol 15: e2000698
Bicker F, Vasic V, Horta G, Ortega F, Nolte H, Kavyanifar A, Keller S, Stankovic ND, Harter PN, Benedito R, Lutz B, Bäuerle T, Hartwig J, Baumgart J, Krüger M, Radyushkin K, Alberi L, Berninger B, Schmidt MHH (2017) Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception. Nat Commun 8: 15922
Farrukh A, Ortega F, Fan W, Marichal N, Paez JI, Berninger B, Campo AD, Salierno MJ (2017) Bifunctional Hydrogels Containing the Laminin Motif IKVAV Promote Neurogenesis. Stem Cell Reports 9: 1432-1440