Phillip Gordon-Weeks

Phillip Gordon-Weeks

Emeritus Professor, Group Leader


My Ph.D supervisor was Prof. E. George Gray FRS and in his laboratory in the Anatomy Department at University College London I learnt electron microscopy and became interested in microtubules. When George was appointed head of the newly established Laboratory of Biological Ultrastructure at the Medical Research Council�s National Institute for Medical Research in Mill Hill, London, he asked me to go with him and I was there for 4 years pursuing my interest in microtubules in neurons. I was then appointed to a Research Fellowship in the Brain Research Group at the Open University, Milton Keynes, where I started to work on neuronal growth cones and supervised my first Ph. D student, Owen Lockerbie. Owen and I development a method for the isolation of neuronal growth cones as a subcellular fraction from developing brain for biochemical and physiological analysis. Since then our method has been widely used. In 1985 I was appointed to a lectureship in the Department of Anatomy and Human Biology at King�s College London where, in 1990, I helped to establish the Developmental Biology Research Centre. In 2000, I published a monograph on growth cones: �Neuronal Growth Cones�, Developmental & Cell Biology Monograph Series, Cambridge University Press, which is now available in electronic format. When King�s merged with UMDS, I became a founding member of the MRC Centre for Developmental Neurobiology.


Thompson Reuters Researcher ID: C-5328-2009

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All publications:


Poobalasingam T, Bianco F, Oozeer F, Gordon-Weeks PR (2022) The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons. J Neurochem 160: 185-202


Gordon-Weeks PR (2017) Phosphorylation of Drebrin and Its Role in Neuritogenesis. Adv Exp Med Biol 1006: 49-60
Dart AE, Gordon-Weeks PR (2017) The Role of Drebrin in Cancer Cell Invasion. Adv Exp Med Biol 1006: 375-389
Dart AE, Worth DC, Muir G, Chandra A, Morris JD, McKee C, Verrill C, Bryant RJ, Gordon-Weeks PR (2017) The drebrin/EB3 pathway drives invasive activity in prostate cancer. Oncogene 36: 4111-4123

Trivedi N, Stabley DR, Cain B, Howell D, Laumonnerie C, Ramahi JS, Temirov J, Kerekes RA, Gordon-Weeks PR, Solecki DJ (2017) Drebrin-mediated microtubule-actomyosin coupling steers cerebellar granule neuron nucleokinesis and migration pathway selection. Nat Commun 8: 14484


Stiber JA, Wu JH, Zhang L, Nepliouev I, Zhang ZS, Bryson VG, Brian L, Bentley RC, Gordon-Weeks PR, Rosenberg PB, Freedman NJ (2016) The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia. Arterioscler Thromb Vasc Biol 36: 984-93
Gordon-Weeks PR (2016) The role of the drebrin/EB3/Cdk5 pathway in dendritic spine plasticity, implications for Alzheimer's disease. Brain Res Bull 126: 293-299


Sonego M, Oberoi M, Stoddart J, Gajendra S, Hendricusdottir R, Oozeer F, Worth DC, Hobbs C, Eickholt BJ, Gordon-Weeks PR, Doherty P, Lalli G (2015) Drebrin regulates neuroblast migration in the postnatal Mammalian brain. PLoS One 10: e0126478


Worth DC, Daly CN, Geraldo S, Oozeer F, Gordon-Weeks PR (2013) Drebrin contains a cryptic F-actin-bundling activity regulated by Cdk5 phosphorylation. J Cell Biol 202: 793-806