Mark  Richardson

Mark Richardson

Paul Getty III Professor in Epilepsy



The Richardson Lab, headed by Professor Mark Richardson, comprises a team of epilepsy researchers from several different disciplines, including neurology, psychology, engineering and physics. We study the human brain as an entire functioning system, rather than studying small components of the brain. In order to do this, we use brain scanning techniques (especially MRI) and electroencephalography (EEG, a method to record electrical activity from the brain), as well as transcranial magnetic brain stimulation (TMS). We are especially interested to create simplified models of the brain using computers, which can provide important insights into the workings of the highly complex brain. Our current programme is focussed on understanding how seizures emerge as the result of the complex interplay between the neuronal dynamics of localised brain regions, and the interconnectivity between these regions. We are particularly interested to discover whether these features are genetically determined, and how these features develop through childhood and into adult life.

All publications:


Bauer PR, de Goede AA, Stern WM, Pawley AD, Chowdhury FA, Helling RM, Bouet R, Kalitzin SN, Visser GH, Sisodiya SM, Rothwell JC, Richardson MP, van Putten MJAM, Sander JW (2018) Long-interval intracortical inhibition as biomarker for epilepsy: a transcranial magnetic stimulation study. Brain 141: 409-421


Perani S, Tierney TM, Centeno M, Shamshiri EA, Yaakub SN, O'Muircheartaigh J, Carmichael DW, Richardson MP (2017) Thalamic volume reduction in drug-naive patients with new-onset genetic generalized epilepsy. Epilepsia


Keller SS, Richardson MP, Schoene-Bake JC, O'Muircheartaigh J, Elkommos S, Kreilkamp B, Goh YY, Marson AG, Elger C, Weber B (2015) Thalamotemporal alteration and postoperative seizures in temporal lobe epilepsy. Ann Neurol 77: 760-74


Schmidt H, Petkov G, Richardson MP, Terry JR (2014) Dynamics on networks: the role of local dynamics and global networks on the emergence of hypersynchronous neural activity. PLoS Comput Biol 10: e1003947


Richardson MP (2012) Large scale brain models of epilepsy: dynamics meets connectomics. J Neurol Neurosurg Psychiatry 83: 1238-48


Traynor CR, Barker GJ, Crum WR, Williams SC, Richardson MP (2011) Segmentation of the thalamus in MRI based on T1 and T2. Neuroimage 56: 939-50


Traynor C, Heckemann RA, Hammers A, O'Muircheartaigh J, Crum WR, Barker GJ, Richardson MP (2010) Reproducibility of thalamic segmentation based on probabilistic tractography. Neuroimage 52: 69-85


Wright MA, Orth M, Patsalos PN, Smith SJ, Richardson MP (2006) Cortical excitability predicts seizures in acutely drug-reduced temporal lobe epilepsy patients. Neurology 67: 1646-51