Karen Yap

Karen Yap

Research Associate


Makeyev group

Biography:

Degree in National University of Singapore

PhD in Nanyang Technological University

Worked as a Clinical Trial Coordinator in Singapore General Hospital

Current project: Understanding the regulation of alternative splicing in neurodevelopment.

Related News:

Hybridisation-proximity labelling sheds new light on subcellular compartments

04/11/21
New findings from the Makeyev lab

Long noncoding RNAs and their diverse influences

16/10/18
"Meaningless" part of genome has important cellular functions and can promote malignancy

Selected publications:

Selected Publications

Yap K, Chung TH, Makeyev EV (2022) Hybridization-proximity labeling reveals spatially ordered interactions of nuclear RNA compartments. Mol Cell 82: 463-478.e11
Yap K, Mukhina S, Zhang G, Tan JSC, Ong HS, Makeyev EV (2018) A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival. Mol Cell
Verbeeren J, Verma B, Niemelä EH, Yap K, Makeyev EV, Frilander MJ (2017) Alternative exon definition events control the choice between nuclear retention and cytoplasmic export of U11/U12-65K mRNA. PLoS Genet 13: e1006824
Yap K, Xiao Y, Friedman BA, Je HS, Makeyev EV (2016) Polarizing the Neuron through Sustained Co-expression of Alternatively Spliced Isoforms. Cell Rep 15: 1316-28