Juan Burrone

Juan Burrone

Professor of Developmental Neurophysiology, Group Leader


Development of functional neuronal networks

Biography:

Juan Burrone graduated from the University of Bristol, UK, in 1995 with a BSc in Biochemistry. He then obtained a PhD from Cambridge University in 2000, having worked under the supervision of Prof. Leon Lagnado at the MRC Laboratory of Molecular Biology (LMB). He then moved to the Molecular and Cellular Biology department at Harvard University, USA, to join Prof. Venkatesh Murthy?s lab as a postdoctoral fellow. In 2006 he joined the MRC Centre for Developmental Neurobiology as a lecturer, where he is currently a professor.

He has received many recognitions and awards, including a NARSAD Young Investigator Award (2000); Grable investigator of NARSAD (2001); Wellcome Value in People (VIP) award (2005); Lister Institute Prize winner (2009); Wellcome Trust Young Investigator award (2011); ERC Young Investigator award (2011).

Links:

Thompson Reuters Researcher ID: C-5654-2009
KCL PURE: https://kclpure.kcl.ac.uk/portal/juan.burrone.html

Related News:

Synapse safari: a journey into citizen science

28/11/25
2,000 volunteers and tens of thousands of segmented synaptic boutons

Juan Burrone and Ivo Lieberam awarded MRC Programme Grant

12/08/24
Grant awarded to investigate novel potential strategy for ALS rescue

The Epilepsy Research Institute Launch at 10 Downing Street

25/10/23
Professor Juan Burrone appointed Co-Lead for the Epilepsy Research Institute

All Publications:

2026

Shallcross T, Diana G, Burrone J, Meyer M (2026) Spatial subdomains in the Optic Tectum for the encoding of visual information. J Neurosci

2025

Joseph BJ, Marshall KA, Harley P, Mann JR, Alessandrini F, Vanoye CG, Chi W, Prudencio M, Simkin D, Kao TT, Desai RR, Keuss MJ, Barattucci S, Zanovello M, Mehta PR, DeKeyser JM, Limone F, Lee J, Brown AL, Leyton-Jaimes MF, Nash LA, Juan IGS, Aronica E, Wainger BJ, Shah M, Goswami A, Shneider NA, Dickson DW, Burrone J, Zhang C, Wichterle H, Petrucelli L, Watts JK, George AL, Fratta P, Eggan K, Kiskinis E (2025) TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD. Nat Neurosci

Lenherr C, Neves G, de Oliveira MG, Burrone J (2025) Bringing Chandelier Cells Out of the Shadows: Exploring the Development of a Unique Neuron Type in the Brain. Cold Spring Harb Perspect Biol

Ritzau-Jost A, Rajayer S, Nerlich J, Maciag F, John A, Russier M, Sabater VG, Steiger LJ, Coq JO, Eilers J, Engelhardt M, Burrone J, Debanne D, Heine M, Smith SM, Hallermann S (2025) Unreliable homeostatic action potential broadening in cultured dissociated neurons. bioRxiv

Konishi K, Neves G, Russell M, Mimura M, Burrone J, Fleck R (2025) A workflow for semi-automated volume correlative light microscopy and transmission electron tomography. J Microsc

2024

Keuss MJ, Harley P, Ryadnov E, Jackson RE, Zanovello M, Wilkins OG, Barattucci S, Mehta PR, Oliveira MG, Parkes JE, Sinha A, Correa-Sánchez AF, Oliver PL, Fisher EMC, Schiavo G, Shah M, Burrone J, Fratta P (2024) Loss of TDP-43 induces synaptic dysfunction that is rescued by UNC13A splice-switching ASOs. bioRxiv

Keuss MJ, Harley P, Ryadnov E, Jackson RE, Zanovello M, Wilkins OG, Barattucci S, Mehta PR, Oliveira MG, Parkes JE, Sinha A, Correa-Sánchez AF, Oliver PL, Fisher EMC, Schiavo G, Shah M, Burrone J, Fratta P (2024) Loss of TDP-43 induces synaptic dysfunction that is rescued by UNC13A splice-switching ASOs. bioRxiv
Keuss MJ, Harley P, Ryadnov E, Jackson RE, Zanovello M, Wilkins OG, Barattucci S, Mehta PR, Oliveira MG, Parkes JE, Sinha A, Correa-Sánchez AF, Oliver PL, Fisher EMC, Schiavo G, Shah M, Burrone J, Fratta P (2024) Loss of TDP-43 induces synaptic dysfunction that is rescued by UNC13A splice-switching ASOs. bioRxiv

Horton S, Mastrolia V, Jackson RE, Kemlo S, Pereira Machado PM, Carbajal MA, Hindges R, Fleck RA, Aguiar P, Neves G, Burrone J (2024) Excitatory and inhibitory synapses show a tight subcellular correlation that weakens over development. Cell Rep

Mateus JC, Sousa MM, Burrone J, Aguiar P (2024) Beyond a Transmission Cable-New Technologies to Reveal the Richness in Axonal Electrophysiology. J Neurosci

2023

Harley P, Kerins C, Gatt A, Neves G, Riccio F, Machado CB, Cheesbrough A, R'Bibo L, Burrone J, Lieberam I (2023) Aberrant axon initial segment plasticity and intrinsic excitability of ALS hiPSC motor neurons. Cell Rep

Puhl CJ, Wefelmeyer W, Burrone J (2023) Cholinergic Stimulation Modulates the Functional Composition of CA3 Cell Types in the Hippocampus. J Neurosci

Rigby M, Grillo FW, Compans B, Neves G, Gallinaro J, Nashashibi S, Horton S, Pereira Machado PM, Carbajal MA, Vizcay-Barrena G, Levet F, Sibarita JB, Kirkland A, Fleck RA, Clopath C, Burrone J (2023) Multi-synaptic boutons are a feature of CA1 hippocampal connections in the stratum oriens. Cell Rep

Compans B, Burrone J (2023) Chandelier cells shine a light on the formation of GABAergic synapses. Curr Opin Neurobiol

2022

Jackson RE, Compans B, Burrone J (2022) Correlative Live-Cell and Super-Resolution Imaging to Link Presynaptic Molecular Organisation With Function. Front Synaptic Neurosci