Darren Williams

Darren Williams

Reader, Group leader



Biography:

Darren Williams is a Reader and Group Leader within the Department for Developmental Neurobiology. He became fascinated by insect nervous system development and metamorphosis as a postdoc in David Shepherd’s lab, at the University of Southampton and then went to work with Jim Truman at the University of Washington, studying the effect of steroid hormones on neuronal remodelling.

His work has elucidated fundamental aspects of early developmental events within the nervous system, particularly how the anatomy and function of lineally related neurons are specified, using the thoracic nervous system of Drosophila as a model. Alongside this, he has explored late developmental events that help sculpt neuronal connections, pioneering live imaging approaches in pupal stages.

By focusing on fundamental questions he has revealed mechanisms pertinent to the development all nervous systems. He has been funded by the MRC, the BBSRC, the Wellcome Trust, HHMI and the Royal Society

He is passionate about teaching and talking to non-scientists about science.

Links:

Thompson Reuters Researcher ID: C-5356-2009
KCL PURE: https://kclpure.kcl.ac.uk/portal/darren.williams.html

Related News:

Brain Awareness Week Science Café!

06/04/17
Zombie neurons and the dark network!

All publications:

2019

Shepherd D, Sahota V, Court R, Williams DW, Truman JW (2019) Developmental organization of central neurons in the adult Drosophila ventral nervous system. J Comp Neurol 527: 2573-2598

2018

Constance WD, Mukherjee A, Fisher YE, Pop S, Blanc E, Toyama Y, Williams DW (2018) Neurexin and Neuroligin-based adhesion complexes drive axonal arborisation growth independent of synaptic activity. Elife 7: e31659

2017

Mukherjee A, Williams DW (2017) More alive than dead: non-apoptotic roles for caspases in neuronal development, plasticity and disease. Cell Death Differ 24: 1411-1421

2016

Shepherd D, Harris R, Williams DW, Truman JW (2016) Postembryonic lineages of the Drosophila ventral nervous system: Neuroglian expression reveals the adult hemilineage associated fiber tracts in the adult thoracic neuromeres. J Comp Neurol 524: 2677-95

2015

Loncle N, Agromayor M, Martin-Serrano J, Williams DW (2015) An ESCRT module is required for neuron pruning. Sci Rep 5: 8461

2013

Hay DB, Williams D, Stahl D, Wingate RJ (2013) Using Drawings of the Brain Cell to Exhibit Expertise in Neuroscience: Exploring the Boundaries of Experimental Culture Science Education 93 (3): 468-491

2012

Loncle N, Williams DW (2012) An interaction screen identifies headcase as a regulator of large-scale pruning. J Neurosci 32: 17086-96

2011

Brierley D, Rathore K, Vijayraghavan K, Williams D (2011) Developmental origins and architecture of Drosophila leg motoneurons. J Comp Neurol