Karen Yap

Karen Yap

Research Associate


Makeyev group

Biography:

Degree in National University of Singapore

PhD in Nanyang Technological University

Worked as a Clinical Trial Coordinator in Singapore General Hospital

Current project: Understanding the regulation of alternative splicing in neurodevelopment.

Related News:

Hybridisation-proximity labelling sheds new light on subcellular compartments

04/11/21
New findings from the Makeyev lab

Long noncoding RNAs and their diverse influences

16/10/18
"Meaningless" part of genome has important cellular functions and can promote malignancy

All publications:

2022

Yap K, Chung TH, Makeyev EV (2022) Analysis of RNA-containing compartments by hybridization and proximity labeling in cultured human cells. STAR Protoc 3: 101139

2018

Yap K, Mukhina S, Zhang G, Tan JSC, Ong HS, Makeyev EV (2018) A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival. Mol Cell

2017

Verbeeren J, Verma B, Niemelä EH, Yap K, Makeyev EV, Frilander MJ (2017) Alternative exon definition events control the choice between nuclear retention and cytoplasmic export of U11/U12-65K mRNA. PLoS Genet 13: e1006824

2016

Yap K, Xiao Y, Friedman BA, Je HS, Makeyev EV (2016) Polarizing the Neuron through Sustained Co-expression of Alternatively Spliced Isoforms. Cell Rep 15: 1316-28

2014

Neo WH, Yap K, Lee SH, Looi LS, Khandelia P, Neo SX, Makeyev EV, Su IH (2014) MicroRNA miR-124 controls the choice between neuronal and astrocyte differentiation by fine-tuning Ezh2 expression. J Biol Chem 289: 20788-801

2013

Yap K, Makeyev EV (2013) Regulation of gene expression in mammalian nervous system through alternative pre-mRNA splicing coupled with RNA quality control mechanisms. Mol Cell Neurosci 56: 420-8