Centre for Developmental Neurobiology
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Research Highlights
Research Highlights
Authentic conversion of astroglia into cortical interneuron-like neurons
21/10/24
Key advancement in engineering neuronal fates unveiled by Berninger lab
Gene regulation in developing neurons: factRing in alternative splicing and nonsense-mediated decay
04/07/24
New findings from the Makeyev and Hamid labs
Alternative splicing controls teneurin-3 compact dimer formation for neuronal recognition
03/07/24
New findings from the Hindges and Drescher labs
Inhibitory synapses provide scaffold to balance growing excitation during early development
03/07/24
Crucial role for inhibitory synapses uncovered
Neurons for activity transition in brain development identified
09/04/24
New findings from the Marín lab
Linking adult neural stem cell activation and tumourigenesis
14/04/23
New work from the Berninger lab
Protocol developed for deriving V3 interneurons
07/02/23
New work from the Lieberam lab
Manufacturing human iPSC-based neuromuscular circuits in compartmented devices
30/01/23
New findings from the Lieberam lab
Spotlight on SARS-CoV-2 in the foetal brain
14/01/23
New publication from the Long lab
PTBP1 links co-transcriptional splicing and epigenetic regulation in developing neurons
10/01/23
New publication from the Makeyev lab
Rapid presynaptic maturation shown in naturally regenerating axons
06/12/22
New publication from the Grubb lab
Cortical wiring by synapse type-specific control of local protein synthesis
24/11/22
New publication from the Marín and Rico labs
Novel ALS hallmark may trigger motor degeneration
22/11/22
New publication from the Houart lab
Spliceosome protein SNRNP70 has critical non-nuclear role in motor function
15/11/22
New publication from the Houart lab
Understanding the subcellular distribution and interactions of teneurins
09/11/22
New publication from the Hindges lab
Neuronal polarity and excitability
13/09/22
A tale of two compartments
Input-specific modulation of interneuron survival
05/07/22
Publication from the Marín lab in
Cell Reports
Control of interneuron numbers in nascent striatal networks
10/05/22
New publication from the Marín lab
Learning and attention are mechanistically distinct
13/12/21
New paper from the Khan lab
Interneuron development conserved between mouse and human
10/12/21
New paper from the Marín lab
Hybridisation-proximity labelling sheds new light on subcellular compartments
04/11/21
New findings from the Makeyev lab
Reprogramming epilepsy
30/09/21
Glia-to-neuron reprogramming reduces chronic seizures
First neuromuscular circuit model for Duchenne Muscular Dystrophy
10/09/21
New paper from the Lieberam lab out now in Science Advances
'Don't mind the heat'
11/06/21
New study from Ch'ng lab
How
CHD8
mutations can disrupt ASD-relevant circuits in the cortex
12/04/21
New paper out now from the Andreae lab
Gene regulation mechanism impacting diverse neuropathologies uncovered
26/03/21
SFPQ plays key role in neuronal development
Novel strategy for assembly of cortical circuits revealed
04/01/21
Paper from Rico and Marín labs out now in
eLife
Nomenclature for the Drosophila ventral nerve cord
28/09/20
New nomenclature proposed, out now in
Neuron
Neurodevelopment viewed through big data lens
17/09/20
Review from Oscar Marín in press at
Science
Loss of smell in COVID-19 investigated
21/04/20
Expression of SARS-CoV2 receptor points to mechanisms of olfactory dysfunction
Deciphering the tubulin code
24/02/20
Tuba8 has an instructive role in progenitor differentiation
A new mechanism for maintaining pluripotency
15/01/20
Insights into cell type-specific gene expression and novel therapeutic applications
Reimagining the remarkable diversity in the cortex
20/12/19
A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture
Unexpected role for Dkk1
02/12/19
Novel mechanism revealed for protein implicated in cancer and neurodegeneration
Mixed origins of ‘the third eye’
27/11/19
Descartes had a point...
Novel method for inferring neuronal assemblies
11/11/19
Using Bayesian inference to understand how brain computations are distributed across neural networks
The elusive fifth pharyngeal arch
16/09/19
Rethinking the numbering of the amniote pharyngeal arches
Reliable brain tissue clearing method
21/08/19
Protocol and quantitative assessment published for hydrogel-based brain tissue clearing
There’s a time and a place for differentiation
11/07/19
Protrusive activity of newborn neurons organises long-distance pattern of differentiation
New method to understand ALS developed
22/05/19
Towards a better understanding of the breakdown of the muscle-brain connection in ALS
Suppressing your “inner fish”
13/02/19
Key evolutionary event unveiled that allowed ancestors to emerge from water
The sweet smell of adult neurogenesis
05/02/19
Adult olfactory bulb neurogenesis improves odour distinction
Which came first, the chicken or the mouse?
31/01/19
Research suggests chick auditory network derived from ancient vestibular network
Molecular programs regulate synaptic specificity
25/01/19
Landmark finding: Cell-specific molecular programs determine cortical interneuron connectivity
Long noncoding RNAs and their diverse influences
16/10/18
"Meaningless" part of genome has important cellular functions and can promote malignancy
Neural stem cells and astrogliogenesis
08/10/18
Benedikt Berninger and colleagues identify transcription factors driving astrogliogenesis
Changes in global brain connectivity in epilepsy
27/09/18
Connectivity and synaptic dynamics in epilepsy probed by researchers during epileptic seizures
Axonal arborisation
01/08/18
Researchers uncover how NEK7 kinase commands the shape and wiring of cortical interneurons.
Current Opinion in Neurobiology Editorial
01/08/18
Professor Juan Burrone discusses the past, present and future of cellular neuroscience
Synaptic input organisation in pyramidal neurons
25/07/18
How are synaptic inputs organised along the vast dendritic trees of pyramidal neurons?
Coupling migration & axon targeting optimisation
21/06/18
Coupling migration and axon targeting optimises the assembly of inhibitory circuits in the cortex
How to build a brain: discovery solves evolutionary mystery
30/05/18
How the balance of excitatory and inhibitory neurons in the cerebral cortex has remained constant as mammals have evolved
Dialling up neurogenesis safely in vivo
10/05/18
New study demonstrates a means to expand specific neural lineages
in vivo
in a non-tumorigenic way
Dopamine-releasing brain cells
19/04/18
In the mouse olfactory bulb, different types of dopaminergic neuron are generated in prenatal compared to postnatal life.
Seeing the wood for the trees!
12/04/18
Neuron arbor growth is driven by dynamic ‘neuritic adhesion complexes’ containing Neurexin and Neuroligin
New insights into interneuron diversity
22/02/18
The potential identity of cortical interneurons is determined early during embryonic development
Novel way for balancing excitation and inhibition
13/02/18
Researchers from CDN uncovered a novel mechanism that determines how the number of inhibitory interneurons is established in the cortex
How neurons sense our everyday life
13/07/17
Researchers from CDN have discovered a molecular mechanism that enables neuronal connections to change through experience
New insights into motor neuron development
13/04/17
A new understanding of the role of splicing factors in motor development
Brain cells that keep mice active
11/04/17
Researchers have discovered a type of brain cell that prevents mice from being overly immobile
A little inhibition shapes the brain’s GPS
10/04/17
Inhibitory neurons in the cerebral cortex play a key role in how the brain encodes spatial information
Disrupting prostate cancer ‘homing signal’ could hold promise for new treatments
20/03/17
How cancer cells escape the prostate and spread to other parts of the body.
Genes control how information is duplicated in the nervous system
07/02/17
New study reveals identifies some of the first genes that perform this function.
A molecular switch helps interneurons find their way in the cortex
31/01/17
Nrg3 attracts and guides the movement of interneurons during migration in the brain.
Zebrafish reveal the ups and downs of vision
30/06/16
Researchers shed light on how we perceive and recognise specific visual stimuli.
Co-expression helps neurons take shape
28/04/16
New study suggests that co-expression of alternatively spliced isoforms plays a role in neurons complex shapes and functions.
A new mechanism for nerve growth
24/02/16
A new mechanism for guiding axons across the midline has been documented.
Manipulating proteins with light
14/01/16
Researchers detail a method that can rapidly and reversibly manipulate protein in targeted embryonic cells.
Deciphering the role of brain layers
19/11/15
New research finds cortical lamination speeds up neuronal circuit formation, but is not an essential feature for circuit function.
New insight into how neurons regulate their activity
29/10/15
Plastic adaptation in the axonal initial segment (AIS) happens more rapidly than has previously been shown
Brain cells get tweaked 'on the go'
10/09/15
Researchers have discovered a new molecular 'switch' that controls the properties of neurons in response to changes in the activity of their neural network.
Static synapses, moving structures: Mind the gap!
21/07/15
Researchers from the MRC CDN characterises a novel way in which neurons remain electrically stable when confronted with chronic increases in neuronal activity.
How to rule a gene galaxy
06/07/15
Researchers from the MRC CDN and the USA describe a wide-area regulatory mechanism for neuronal differentiation.
Interneurons find their way to the striatum
10/06/15
Researchers at King's have identified a parallel mechanism of attraction and repulsion during cortical and striatal interneuron migration.
Deciphering the neural code that links food to age
12/05/15
Diet exerts a major impact on health and ageing. The nervous system plays an important role in this process but, thus far, how food signals are interpreted by the nervous system has been a mystery.
New way that neurons alter their structure
16/03/15
A study by our researchers reveals a new way by which neurons alter their structure in response to changes in their electrical activity.
Membrane cutting protein plays key role in neuron pruning
05/03/15
Our researchers have identified a family of proteins that is essential for cutting neuronal branches during pruning.
