Centre for Developmental Neurobiology
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Affiliated Group Leaders
MRC DTP & KBI Programme
Glow in the Dark Science
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Loss of smell in COVID-19 investigated
Expression of SARS-CoV2 receptor points to mechanisms of olfactory dysfunction
Deciphering the tubulin code
Tuba8 has an instructive role in progenitor differentiation
A new mechanism for maintaining pluripotency
Insights into cell type-specific gene expression and novel therapeutic applications
Reimagining the remarkable diversity in the cortex
A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture
Unexpected role for Dkk1
Novel mechanism revealed for protein implicated in cancer and neurodegeneration
Mixed origins of ‘the third eye’
Descartes had a point...
Novel method for inferring neuronal assemblies
Using Bayesian inference to understand how brain computations are distributed across neural networks
The elusive fifth pharyngeal arch
Rethinking the numbering of the amniote pharyngeal arches
Reliable brain tissue clearing method
Protocol and quantitative assessment published for hydrogel-based brain tissue clearing
There’s a time and a place for differentiation
Protrusive activity of newborn neurons organises long-distance pattern of differentiation
New method to understand ALS developed
Towards a better understanding of the breakdown of the muscle-brain connection in ALS
Suppressing your “inner fish”
Key evolutionary event unveiled that allowed ancestors to emerge from water
The sweet smell of adult neurogenesis
Adult olfactory bulb neurogenesis improves odour distinction
Which came first, the chicken or the mouse?
Research suggests chick auditory network derived from ancient vestibular network
Molecular programs regulate synaptic specificity
Landmark finding: Cell-specific molecular programs determine cortical interneuron connectivity
Long noncoding RNAs and their diverse influences
"Meaningless" part of genome has important cellular functions and can promote malignancy
Neural stem cells and astrogliogenesis
Benedikt Berninger and colleagues identify transcription factors driving astrogliogenesis
Changes in global brain connectivity in epilepsy
Connectivity and synaptic dynamics in epilepsy probed by researchers during epileptic seizures
Researchers uncover how NEK7 kinase commands the shape and wiring of cortical interneurons.
Current Opinion in Neurobiology Editorial
Professor Juan Burrone discusses the past, present and future of cellular neuroscience
Synaptic input organisation in pyramidal neurons
How are synaptic inputs organised along the vast dendritic trees of pyramidal neurons?
Coupling migration & axon targeting optimisation
Coupling migration and axon targeting optimises the assembly of inhibitory circuits in the cortex
How to build a brain: discovery solves evolutionary mystery
How the balance of excitatory and inhibitory neurons in the cerebral cortex has remained constant as mammals have evolved
Dialling up neurogenesis safely in vivo
New study demonstrates a means to expand specific neural lineages
in a non-tumorigenic way
Dopamine-releasing brain cells
In the mouse olfactory bulb, different types of dopaminergic neuron are generated in prenatal compared to postnatal life.
Seeing the wood for the trees!
Neuron arbor growth is driven by dynamic ‘neuritic adhesion complexes’ containing Neurexin and Neuroligin
New insights into interneuron diversity
The potential identity of cortical interneurons is determined early during embryonic development
Novel way for balancing excitation and inhibition
Researchers from CDN uncovered a novel mechanism that determines how the number of inhibitory interneurons is established in the cortex
How neurons sense our everyday life
Researchers from CDN have discovered a molecular mechanism that enables neuronal connections to change through experience
New insights into motor neuron development
A new understanding of the role of splicing factors in motor development
Brain cells that keep mice active
Researchers have discovered a type of brain cell that prevents mice from being overly immobile
A little inhibition shapes the brain’s GPS
Inhibitory neurons in the cerebral cortex play a key role in how the brain encodes spatial information
Disrupting prostate cancer ‘homing signal’ could hold promise for new treatments
How cancer cells escape the prostate and spread to other parts of the body.
Genes control how information is duplicated in the nervous system
New study reveals identifies some of the first genes that perform this function.
A molecular switch helps interneurons find their way in the cortex
Nrg3 attracts and guides the movement of interneurons during migration in the brain.
Zebrafish reveal the ups and downs of vision
Researchers shed light on how we perceive and recognise specific visual stimuli.
Co-expression helps neurons take shape
New study suggests that co-expression of alternatively spliced isoforms plays a role in neurons complex shapes and functions.
A new mechanism for nerve growth
A new mechanism for guiding axons across the midline has been documented.
Manipulating proteins with light
Researchers detail a method that can rapidly and reversibly manipulate protein in targeted embryonic cells.
Deciphering the role of brain layers
New research finds cortical lamination speeds up neuronal circuit formation, but is not an essential feature for circuit function.
New insight into how neurons regulate their activity
Plastic adaptation in the axonal initial segment (AIS) happens more rapidly than has previously been shown
Brain cells get tweaked 'on the go'
Researchers have discovered a new molecular 'switch' that controls the properties of neurons in response to changes in the activity of their neural network.
Static synapses, moving structures: Mind the gap!
Researchers from the MRC CDN characterises a novel way in which neurons remain electrically stable when confronted with chronic increases in neuronal activity.
How to rule a gene galaxy
Researchers from the MRC CDN and the USA describe a wide-area regulatory mechanism for neuronal differentiation.
Interneurons find their way to the striatum
Researchers at King's have identified a parallel mechanism of attraction and repulsion during cortical and striatal interneuron migration.
Deciphering the neural code that links food to age
Diet exerts a major impact on health and ageing. The nervous system plays an important role in this process but, thus far, how food signals are interpreted by the nervous system has been a mystery.
New way that neurons alter their structure
A study by our researchers reveals a new way by which neurons alter their structure in response to changes in their electrical activity.
Membrane cutting protein plays key role in neuron pruning
Our researchers have identified a family of proteins that is essential for cutting neuronal branches during pruning.