Neuroendocrine networks that influence physiology
In C. elegans and mammals, physiological processes such as ageing and metabolism are influenced by communication between signalling centres in the nervous system and other tissues. Presently, the precise neuroendocrine networks are not fully detailed. To detail these networks, we use computational and genomic approaches to identify molecular signals that modify ageing, development, and other aspects of physiology. We then pinpoint the cells from which they act and the target cells that they act on, to define the connectivity and topology of the signalling networks that control physiology.
Our work focuses on conserved pathways that regulate ageing, metabolism, and other physiological processes. Thus, we anticipate that insights from our studies will reveal biological mechanisms relevant to human ageing, age-related diseases such as Alzheimer's and sarcopenia, as well as metabolic disorders such as obesity and type 2 diabetes.