Much research has been done into how ectodermally-derived cells and tissues are specified during embryonic development, less however is known as to how, once specified, differentiation into specific cell types occurs. An important gap in our knowledge is in understanding the forces that drive this differentiation and subsequent morphogenesis of cells. I have been interested in the molecular cues that partition the ectoderm to become neural (Muñoz-Sanjuán et al, 2002; Bell et al, 2003) and how different territories are regionalized (Bates et al, 2013). Once specified, a key question that follows is how cells within the neuralised territories are organised to perform the distinctive behaviours that define their first steps in differentiation to distinct fates. These early differentiation behaviours include epithelial thickening and folding, delamination and migration, and are essential to the development of the peripheral and central nervous system.