RNA-based regulation of gene expression in neurodevelopment and disease

Eugene Makeyev

Professor of Molecular Biosciences

Eukaryotic gene expression is extensively regulated at the RNA level. We study biological functions of alternative pre-mRNA splicing and noncoding RNAs in normal development of the nervous system and in the context of neurodegenerative diseases and cancer. The approaches we use range from RNA biology, various "omic" techniques and bioinformatics to stem cell biology, developmental biology and mammalian genetics.

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