Post-transcriptional regulation of gene expression in developing neurons

Eugene Makeyev


The human body contains hundreds of cell types originating through differentiation of multipotent precursors. The process of cellular differentiation relies on a series of important choices, from deciding whether to proliferate or exit the mitotic cycle, to committing to a specific cellular fate. At the molecular level, differentiation requires large-scale changes in the gene expression program. The precursor-specific genes have to be down-regulated whereas batteries of “specialist” genes have to be turned on in differentiation-committed cells. A remarkable aspect of these transitions is that they occur in a highly coordinated manner. We want to understand the mechanisms underlying this synchrony.

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