Comparative studies of CNS development

Corinne Houart

Deputy Director, Professor of Developmental Neurobiology

The Houart Lab aims to understand the cellular, molecular and morphogenetic mechanisms required to build the vertebrate forebrain. Comparative studies using zebrafish and mouse are designed to explore the regulatory changes generating forebrain diversity in vertebrates. We are exploring the impact of signalling pathways in cell migration and identifying key downstream targets of proteins triggering neurodegeneration in Amyotropic Lateral Sclerosis (ALS) and Human Spastic Paraplegia (HSP). Cell ablation and transplantation, genetics, high-throughput molecular biology and in vivo imaging are used to achieve our goals.

Related News:

Mixed origins of ‘the third eye’

Descartes had a point...

New insights into motor neuron development

A new understanding of the role of splicing factors in motor development