The Houart Lab aims to understand the cellular, molecular and morphogenetic mechanisms required to build the vertebrate forebrain. Comparative studies using zebrafish and mouse are designed to explore the regulatory changes generating forebrain diversity in vertebrates. We are exploring the impact of signalling pathways in cell migration and identifying key downstream targets of proteins triggering neurodegeneration in Amyotropic Lateral Sclerosis (ALS) and Human Spastic Paraplegia (HSP). Cell ablation and transplantation, genetics, high-throughput molecular biology and in vivo imaging are used to achieve our goals.
I have an MRC DTP PhD studentship available for the 2019 cohort: 'Coordination of forebrain and sense organ development in vertebrates' (project 20.1, Theme 1).
Follow the link for more information.
Applications for the 2020 MRC DTP studentships will open in mid-October 2019.